Phenacyl bromide → HCID 135418313, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[C:7]2[N:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][C:4](=[O:12])[N:3]=1.Br[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O>CN(C)C=O>[C:17]1([C:15]2[N:1]=[C:2]3[C:7]4[N:8]=[CH:9][CH:10]=[CH:11][C:6]=4[NH:5][C:4](=[O:12])[N:3]3[CH:14]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 150 °C
Versuchsvorschrift
A mixture of 4-Amino-pyrido[2,3-e]pyrimidin-2-one (95 mg) and α-bromo-acetophenone (117 mg) in 4 mL of dimethylformamide (DMF) was heated at about 150° C. for 20 min. The reaction mixture was concentrated in vacuo and the residue was subjected to flash chromatography on silica gel with 10% methanol/methylene chloride as the eluent to afford 2-Phenyl-imidazo[1,2-c]pyrido[2,3-e]pyrimidin-5(6H)-one. (Compound 15), m.p. 329-330° C.