Sodium Hydroxide → 2-Carbamyl-4-hexadecylaminothiophene

HRID 850961Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 850961
[CH2:1]([NH:17][C:18]1[CH:19]=[C:20]([C:23]#[N:24])[S:21][CH:22]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH-:25].[Na+]>COCCO>[C:23]([C:20]1[S:21][CH:22]=[C:18]([NH:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH:19]=1)(=[O:25])[NH2:24]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 131349914-Hexadecylamino-2-cyanothiophene

Produkt 1

HCID 131349932-Carbamyl-4-hexadecylaminothiophene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80192-MethoxyethanolLösungsmittel

Versuchsvorschrift

A mixture of 6.9 g. of 4-hexadecylamino-2-cyanothiophene, 80 ml. of methyl cellosolve, and 80 ml. of 1 N sodium hydroxide is refluxed for 21 hours. After cooling in an ice bath, the solid is filtered and thoroughly washed with methylene chloride. The solid is then added to 100 ml. of water and 5 ml. of concentrated hydrochloric acid and stirred for 8 hours. The solid is filtered and recrystallized from isopropanol.

Aufarbeitung

  1. additionA mixture of 6.9 g
  2. temperatureAfter cooling in an ice bath
  3. filtrationthe solid is filtered
  4. washthoroughly washed with methylene chloride
  5. additionThe solid is then added to 100 ml
  6. filtrationThe solid is filtered
  7. customrecrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-b644d3a0e3614ba791118f70976f2154
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04382143

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