Nitric Acid → Ethyl 5-nitrothiophene-2-carboxylate
Reaktionsgleichung
C(OC(=O)C)(=O)C.[N+:8]([O-:11])(O)=[O:9].[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[N+:8]([C:16]1[S:12][C:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:14][CH:15]=1)([O-:11])=[O:9]Komponenten
4
Versuchsvorschrift
To 160 ml. of acetic anhydride cooled to -5° in an ice-salt bath is added 34 ml. of 90% nitric acid dropwise so that the temperature does not rise above 0°. To this mixture is added 62.7 g. of ethyl 2-thiophenecarboxylate dropwise so that the temperature remains below -5°. Reaction is stirred for 1 hour and poured onto ice. The product is filtered, dried, and recrystallized from hexane.
Aufarbeitung
- additionis added 34 ml
- customdoes not rise above 0°
- additionTo this mixture is added 62.7 g
- customremains below -5°
- customReaction
- additionpoured onto ice
- filtrationThe product is filtered
- customdried
- customrecrystallized from hexane
Quellen und Nachweise
- ORD-Eintrag
- ord-0a34c26d5c7e47c7b60e97902ce9adb0
- Quelldatensatz
- uspto-grants-1983_05
- Patentnummer
- US04382143
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