Ammonia → 3-bromo-4-fluorobenzamide

HRID 851288

Reaktionsgleichung

Reaktionsgleichung von HRID 851288
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](F)=[O:6].[NH3:12]>O>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([NH2:12])=[O:6]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 129227073-Bromo-4-fluorobenzoyl fluoride

Produkt 1

HCID 27733293-bromo-4-fluorobenzamideAusbeute 97,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

800 g (3.6 moles) of 3-bromo-4-fluoro-benzoyl fluoride were metered into 760 g of 25% strength aqueous ammonia solution (11 moles of NH3), which had been diluted with a further 760 ml of water, at a rate such that an internal temperature of 40° to 50° C. was maintained by the weakly exothermic reaction. After stirring for a further 30 minutes, the crystalline product was isolated by filtration, washed with water and dried. 765 g (97% of theory) of 3-bromo-4-fluoro-benzoic acid amide with a melting point of 131°-133° C. were obtained.

Aufarbeitung

  1. temperaturewas maintained by the weakly exothermic reaction
  2. customthe crystalline product was isolated by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-527d56ffb1b642458984fd470ca31e41
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04383949

Verknüpfte Notizen

Wird geladen…