5-Methyl-4-(4-nitro-phenyl)-imidazole → 4-(5-Methyl-1H-imidazol-4-yl)aniline

HRID 851748Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 851748
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1.[H][H]>CO.[Pd]>[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1

Komponenten

5

Edukt 2

HCID 235073515-Methyl-4-(4-nitro-phenyl)-imidazoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 235076304-(5-Methyl-1H-imidazol-4-yl)anilineAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Sixty grams of 5-methyl-4-(4-nitrophenyl)-1-H-imidazole dissolved in methanol was hydrogenated in the presence of 0.7 gm of 5% Pd catalyst at atmospheric pressure and at room temperature. When the calculated amount of hydrogen was taken up, the catalyst was filtered off, and the solution was evaporated to dryness to yield 45 gm of 5-methyl-4-(4-aminophenyl)-1-H-imidazole.

Aufarbeitung

  1. filtrationthe catalyst was filtered off
  2. customthe solution was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-900f2d852ef0466183ad7397bf58a7f1
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04386099

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