Dimethyl Sulfoxide → HCID 54150769, Verbindung

HRID 851809Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 851809
C[O-].[Na+].CO.C1(S([CH2:15][CH2:16][CH2:17][CH:18]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][C:19]2=O)(=O)=O)C=CC=CC=1.CS(C)=O>C1(C)C=CC=CC=1>[C:18]12[CH2:17][CH2:16][CH:15]=[C:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH:29]=2

Komponenten

6

Edukt 4

HCID 679Dimethyl SulfoxideHCID 887MethanolHCID 10942334Sodium MethoxideHCID 205012032-[3-(Benzenesulfonyl)propyl]cyclododecan-1-one

Produkt 1

HCID 54150769HCID 54150769, VerbindungAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

2.37 ml of a 30% solution of sodium methoxide in methyl alcohol (10.2 mmole) were added dropwise to a solution of 0.728 g (2.0 mmole) of 2-(3-phenylsulfonyl-prop-1-yl)-cyclododecanone in 10 ml of toluene as indicated sub letter (b). After 90 min. of heating, 0.57 ml (8.0 mmole) of dimethylsulfoxide (DMSO) were added to the reaction mixture which was then heated to reflux for 4 further hours. After extraction and distillation, there were isolated 0.310 g (76% yield) of the desired compound.

Aufarbeitung

  1. temperatureAfter 90 min. of heating
  2. temperaturewas then heated
  3. temperatureto reflux for 4 further hours
  4. extractionAfter extraction and distillation

Quellen und Nachweise

ORD-Eintrag
ord-4d778dacf7734d94b67b18c12140ad03
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04386220

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