HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
p-Toluidine → 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-p-tolyl-1H-benzo[d]imidazole-4-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | p-Toluidine | HCID 7813 | — |
| Edukt | 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid | HCID 67202138 | — |
| Produkt | 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-p-tolyl-1H-benzo[d]imidazole-4-carboxamide | HCID 67202242 | — |
Reaktionsschritte
2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 159 was coupled with p-toluidine 161 to produce 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-p-tolyl-1H-benzo[d]imidazole-4-carboxamide (Compound 870) using the same general procedure outlined in Example 39. as the starting material. MS (ESI) calcd for C27H25F3N4O: 478.20; found: 479 [M+H].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846947B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-b608400dd2164445873a89842f0999eb |
| Quellennotiz | uspto-grants-2014_09 |