反应详情

2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-4-carboxylic acid 159 was coupled with p-toluidine 161 to produce 2-(4-(pyrrolidin-1-ylmethyl)-2-(trifluoromethyl)phenyl)-N-p-tolyl-1H-benzo[d]imidazole-4-carboxamide (Compound 870) using the same general procedure outlined in Example 39. as the starting material. MS (ESI) calcd for C27H25F3N4O: 478.20; found: 479 [M+H].