Water → 2-{[3-Methoxy-4-(2-thiophene-2-ylvinyl)phenyl]methylamino}ethanol
Reaktionsgleichung
[OH-].[Na+].O.[CH3:4][O:5][C:6]1[CH:7]=[C:8]([CH2:19][NH:20][CH2:21][CH2:22][O:23]C(=O)C(C)(C)C)[CH:9]=[CH:10][C:11]=1[CH:12]=[CH:13][C:14]1[S:15][CH:16]=[CH:17][CH:18]=1>C(O)C>[CH3:4][O:5][C:6]1[CH:7]=[C:8]([CH2:19][NH:20][CH2:21][CH2:22][OH:23])[CH:9]=[CH:10][C:11]=1[CH:12]=[CH:13][C:14]1[S:15][CH:16]=[CH:17][CH:18]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 45 °C
Versuchsvorschrift
NaOH (4.3 g, 107 mmol) was dissolved in ethanol (25 ml), and water (7 ml) was added thereto. Next, 2,2-dimethylpropionic acid 2-{[3-methoxy-4-(2-thiophene-2-ylvinyl)phenyl]methylamino}ethyl ester (4.0 g, 10.7 mmol) was dissolved in ethanol (8 ml) and added dropwise to the mixture. The mixture was stirred at room temperature for 2 hours and further at 45° C. for 1 hour. After the solvent was evaporated off, water (100 ml) was added and the oily matter was subjected to extraction with ethyl acetate. After 2 times of washing with water, drying over Na2SO4 and concentration were performed. The residue was purified by silica gel chromatography to give a yellow oily matter (yield: 3.1 g (100%)).
Aufarbeitung
- additionadded dropwise to the mixture
- customAfter the solvent was evaporated off
- additionwater (100 ml) was added
- extractionthe oily matter was subjected to extraction with ethyl acetate
- washAfter 2 times of washing with water
- dry with materialdrying over Na2SO4 and concentration
- customThe residue was purified by silica gel chromatography
- customto give a yellow oily matter (yield: 3.1 g (100%))
Quellen und Nachweise
- ORD-Eintrag
- ord-46f212c4d6a142638df8ed39582b9f84
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08846955B2
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