Hydrochloric Acid → 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid

HRID 853281Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 853281
OCC(CO)O.[OH-:7].[K+].[CH3:9][O:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15](=[O:21])[CH:16]=[CH:17][NH:18]2)=[CH:13][C:12]=1[C:22]#N.Cl.[OH2:25]>>[CH3:9][O:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15](=[O:21])[CH:16]=[CH:17][NH:18]2)=[CH:13][C:12]=1[C:22]([OH:25])=[O:7]

Komponenten

6

Edukt 5

HCID 313Hydrochloric AcidHCID 753GlycerolHCID 962WaterHCID 14797Potassium HydroxideHCID 229363917-Methoxy-4-oxo-1,4-dihydroquinoline-6-carbonitrile

Produkt 1

HCID 229364397-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

Glycerol (20 ml) and potassium hydroxide (KOH, 3.0 g) were added to the 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carbonitrile (2 g) of Production Example 24, and after heating and stirring at 160° C. for 3 hours, water (40 ml) was added and the mixture was heated at 80° C. for 30 minutes. After cooling, 2N hydrochloric acid was added to acidity and the precipitated insoluble portion was filtered out, washed with water and then dried under reduced pressure to obtain the title compound (1.6 g).

Aufarbeitung

  1. temperatureafter heating
  2. temperaturethe mixture was heated at 80° C. for 30 minutes
  3. temperatureAfter cooling
  4. filtrationthe precipitated insoluble portion was filtered out
  5. washwashed with water
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-34218bb1827e447385f35aca50b30a8a
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253286B2

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