Ethanol → 4-(4-Aminophenoxy)-N-(cyclopropylmethyl)picolinamide

HRID 853454

Reaktionsgleichung

Reaktionsgleichung von HRID 853454
[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[CH:13]=[C:12]([O:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[O:7])[CH2:3][CH2:2]1.[Cl-].[NH4+].C(O)C.CN(C)C=O>[Fe].O>[NH2:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][C:12]2[CH:11]=[CH:10][N:9]=[C:8]([C:6]([NH:5][CH2:4][CH:1]3[CH2:3][CH2:2]3)=[O:7])[CH:13]=2)=[CH:16][CH:17]=1

Komponenten

7

Edukt 4

HCID 702EthanolHCID 6228DimethylformamideHCID 25517Ammonium ChlorideHCID 229368972-[(Cyclopropylmethyl)aminocarbonyl]-4-(4-nitrophenoxy)pyridine

Produkt 1

HCID 589311534-(4-Aminophenoxy)-N-(cyclopropylmethyl)picolinamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

After adding 0.35 g of 2-[(cyclopropylmethyl)aminocarbonyl]-4-(4-nitrophenoxy)pyridine to a mixture of 0.7 g of iron powder, 1.4 g of ammonium chloride, 10 ml of ethanol, 10 ml of dimethylformamide and 5 ml of water, the mixture was vigorously stirred at 100° C. for 20 minutes. The reaction solution was filtered with celite and the solvent was distilled off under reduced pressure to obtain 0.37 g of the target substance as a light brown oil.

Aufarbeitung

  1. filtrationThe reaction solution was filtered with celite
  2. distillationthe solvent was distilled off under reduced pressure
  3. customto obtain 0.37 g of the target substance as a light brown oil

Quellen und Nachweise

ORD-Eintrag
ord-9f89d52ae0eb48c98ef52db059f73ec8
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253286B2

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