Ethanol → 6-(4-Amino-phenoxy)-pyrimidin-4-ylamine

Temperatur

80 °C

After suspending 6-(4-nitrophenoxy)pyrimidin-4-ylamine (306 mg, 1.32 mmol), iron powder (369 mg, 6.60 mmol) and ammonium chloride (706 mg, 13.2 mmol) in an ethanol (20 ml)-water (5 ml) mixed solvent, the suspension was heated and stirred at 80° C. for 20 minutes. After completion of the reaction, the reaction mixture was filtered with celite and washed in ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate, the drying agent was filtered off and the filtrate was concentrated to obtain the title compound (266 mg, 1.32 mmol, 100%) as light yellow crystals.

1. additionmixed solvent
2. temperaturethe suspension was heated
3. customAfter completion of the reaction
4. filtrationthe reaction mixture was filtered with celite
5. washwashed in ethyl acetate
6. washThe organic layer was washed with saturated brine
7. dry with materialdried over anhydrous magnesium sulfate
8. filtrationthe drying agent was filtered off
9. concentrationthe filtrate was concentrated

ORD-Eintrag

ord-e5ccba11d4c444d9ab77d7e1378106a5

Quelldatensatz

uspto-grants-2007_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07253286B2