3-(Benzyloxycarbonylamino)propyl 2-acetoxybenzoate → 3-Aminopropyl 2-acetoxybenzoate

HRID 85354

Reaktionsgleichung

Reaktionsgleichung von HRID 85354
[C:1]([O:4][C:5]1[CH:27]=[CH:26][CH:25]=[CH:24][C:6]=1[C:7]([O:9][CH2:10][CH2:11][CH2:12][NH:13]C(OCC1C=CC=CC=1)=O)=[O:8])(=[O:3])[CH3:2]>[Pd].CO>[C:1]([O:4][C:5]1[CH:27]=[CH:26][CH:25]=[CH:24][C:6]=1[C:7]([O:9][CH2:10][CH2:11][CH2:12][NH2:13])=[O:8])(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 591932393-(Benzyloxycarbonylamino)propyl 2-acetoxybenzoate

Produkt 1

HCID 591932373-Aminopropyl 2-acetoxybenzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 3-(benzyloxycarbonylamino)propyl 2-acetoxybenzoate (2.0 g, 5.4 mmol), 10% Pd/C (0.2 g) and CH3OH (50 mL) was stirred under a H2 atmosphere (RT, 16 h). The mixture was filtered and concentrated under reduced pressure to afford a colorless oil. Purification by silica gel chromatography afforded 3-aminopropyl 2-acetoxybenzoate as a colorless oil. Mass calculated for C12H15NO4=237.25; found: [M+H]+=238.3.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customto afford a colorless oil
  4. customPurification by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e345c465e3cc4d1baf6ce184b46890de
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846972B2

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