Hydrazine hydrate (1:1) → HCID 11392773, Verbindung

HRID 855497Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 855497
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@H:11]2[C@H:15]([OH:16])[C@H:14]([OH:17])[C@@H:13]([CH2:18][OH:19])[O:12]2)=[C:4]([NH:20][CH3:21])[N:3]=1.O.[NH2:23][NH2:24]>>[NH:23]([C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@H:11]2[C@H:15]([OH:16])[C@H:14]([OH:17])[C@@H:13]([CH2:18][OH:19])[O:12]2)=[C:4]([NH:20][CH3:21])[N:3]=1)[NH2:24]

Komponenten

3

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 11243974(4S,2R,3R,5R)-2-[2-chloro-6-(methylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Produkt 1

HCID 11392773HCID 11392773, Verbindung

Versuchsvorschrift

(4S,2R,3R,5R)-2-[2-chloro-6-(methylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol, a compound of formula (2) (0.5 mmol), was suspended in hydrazine hydrate (5 mL), and the mixture was allowed to stir at room temperature for 24 hours. The hydrazine was removed under reduced pressure and the residue triturated with ether and filtered, to afford (4S,2R,3R,5R)-2-[2-hydrazino-6-(methylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol, a compound of formula (3), as a white solid.

Aufarbeitung

  1. customThe hydrazine was removed under reduced pressure
  2. customthe residue triturated with ether
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-2bd1735891764383a4d4279f4a45c891
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07262176B2

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