2-Methoxy-4-nitrobenzenethiol → 4-Amino-2-methoxybenzene-1-thiol

HRID 856696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 856696
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[SH:12]>C(O)(=O)C>[NH2:9][C:7]1[CH:6]=[CH:5][C:4]([SH:12])=[C:3]([O:2][CH3:1])[CH:8]=1

Komponenten

3

Edukt 1

HCID 221487412-Methoxy-4-nitrobenzenethiol

Produkt 1

HCID 193920294-Amino-2-methoxybenzene-1-thiolAusbeute 52,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To 2-methoxy-4-nitrobenzenethiol (7.0 g) was added acetic acid (70 ml), reduced iron (21 g) was added to the mixture, and the mixture was stirred for 6 hours at room temperature. The mixture was filtered with Celite, and washed with ethyl acetate. The solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give 4-amino-2-methoxybenzenethiol (3.1 g).

Aufarbeitung

  1. additionwas added to the mixture
  2. filtrationThe mixture was filtered with Celite
  3. washwashed with ethyl acetate
  4. customThe solvent was removed under reduced pressure
  5. customthe obtained residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-4082bcaf6bfe4ffeb801f5d3bf3cd149
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07262185B2

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