1,3-Dichloroacetone → (4-Chloromethyl-thiazol-2-yl)-naphthalen-1-yl-amine

HRID 857080

Reaktionsgleichung

Reaktionsgleichung von HRID 857080
[C:1]1([NH:11][C:12]([NH2:14])=[S:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:15][CH2:16][C:17]([CH2:19]Cl)=O>CC(C)=O>[Cl:15][CH2:16][C:17]1[N:14]=[C:12]([NH:11][C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)[S:13][CH:19]=1

Komponenten

4

Edukt 2

HCID 107931,3-DichloroacetoneHCID 736366Alpha-Naphthylthiourea

Produkt 1

HCID 21866567(4-Chloromethyl-thiazol-2-yl)-naphthalen-1-yl-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of naphthalen-1-yl-thiourea (iii) (2.02 g, 10 mmol) in acetone (50 mL) at room temperature was added 1,3-dichloroacetone (1.03 g, 10.5 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was filtered and washed with methanol. The filtrate was treated with hexane to afford a white precipitate. The precipitate was filtered and washed with hexane.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. washwashed with methanol
  3. additionThe filtrate was treated with hexane
  4. customto afford a white precipitate
  5. filtrationThe precipitate was filtered
  6. washwashed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-01f4098aa1b34fafbb1a2eada84a92d2
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07144903B2

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