Pyridine → N-[(1R)-1-(4-bromophenyl)ethyl]acetamide

Temperatur

25 °C

To a stirred solution of (R)-(+)-1-(4-bromophenyl)ethylamine (0.52 g, 2.59 mmol) in anhydrous CH2Cl2 (5 mL) under argon were added acetic anhydride (0.37 mL, 3.89 mmol) and Pyridine (0.31 mL, 3.89 mmol). The resulting solution was stirred at 25° C. for 3 hrs. The reaction mixture was quenched with saturated 1 N HCl and extracted with EtOAc (30 mL). The organic phase was washed with brine (50 mL), dried over Na2SO4 and evaporated. The residue was purified by flash column chromatography (80% EtOAc in hexanes) to give the product (0.62 g, 100%) as a white solid.

1. customThe reaction mixture was quenched with saturated 1 N HCl
2. extractionextracted with EtOAc (30 mL)
3. washThe organic phase was washed with brine (50 mL)
4. dry with materialdried over Na2SO4
5. customevaporated
6. customThe residue was purified by flash column chromatography (80% EtOAc in hexanes)

ORD-Eintrag

ord-e11f93c270734f01918ae524961d5629

Quelldatensatz

uspto-grants-2006_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07148226B2