Ethylamine → 2-(4-Bromo-phenyl)-N-ethyl-isobutyramide

HRID 858582

Reaktionsgleichung

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9]([OH:11])=O)=[CH:4][CH:3]=1.C(OCC)(=O)CC(O)=O.[CH2:23]([NH2:25])[CH3:24].BrC1C=CC([C@H](N)C)=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:13])([CH3:12])[C:9]([NH:25][CH2:23][CH3:24])=[O:11])=[CH:6][CH:7]=1

Komponenten

Edukt 4

HCID 6341Ethylamine

HCID 70615Monoethyl malonate

HCID 853000(R)-4-bromo-alpha-methylbenzylamine

HCID 109336792-(4-Bromophenyl)-2-methylpropanoic acid

Produkt 1

HCID 587627102-(4-Bromo-phenyl)-N-ethyl-isobutyramideAusbeute 82 %

Versuchsvorschrift

The title compound was prepared as described in Step 1 of Example A(39), where 2-(4-bromophenyl)-2-methyl propionic acid was substituted for ethyl hydrogen malonate and ethyl amine was substituted for (R)-(+)-1-(4-bromophenyl)ethylamine on that example. Yield 82%.

Quellen und Nachweise

ORD-Eintrag: ord-476a9e99b5da41409abb5d1a1841ed16
Quelldatensatz: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07148226B2

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