Diethyl Ether → Pyridine-4-amidine hydrochloride
Reaktionsgleichung
[Na].[C:2]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)#[N:3].[Cl-:10].[NH4+:11].C(OCC)C>CO>[ClH:10].[C:2]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=[NH:11])[NH2:3]Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of sodium (0.23 g) in methanol (40 ml) was added 4-cyanopyridine (10.62 g) at room temperature. Stirring was continued for 6 h followed by the addition of ammoniumchloride (5.9 g) and stirring was continued for another 10 h. Then diethylether (120 ml) was added and the precipitate was filtered off after 30 min and washed once with diethylether (20 ml). The product was dried under high vacuum. 4-Amidino-pyridine hydrochloride (14.95 g) was obtained as a white powder.
Aufarbeitung
- stirringstirring
- waitwas continued for another 10 h
- filtrationthe precipitate was filtered off after 30 min
- washwashed once with diethylether (20 ml)
- customThe product was dried under high vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-f98f5a335bf343b985a425cce2db865f
- Quelldatensatz
- uspto-grants-2006_08
- Patentnummer
- US07091201B2
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