Water → 2-(4-Bromo-2-ethyl-benzyl)-isoindole-1,3-dione

To 4-bromo-1-bromomethyl-2-ethyl-benzene (4.0 g, 14.2 mmol) in dimethylformamide (100 mL) at room temperature was added potassium phthalimide (2.9 g, 15.6 mmol), and the solution was heated at 80° C. for 5 h. The solution was cooled to room temperature and poured into water. The aqueous solution was extracted with ethyl acetate. The pooled organics were washed with saturated sodium chloride, dried (Na2SO4), filtered, and concentrated in vacuo to a yellow solid (4.0 g, 82%).

1. temperatureThe solution was cooled to room temperature
2. extractionThe aqueous solution was extracted with ethyl acetate
3. washThe pooled organics were washed with saturated sodium chloride
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated in vacuo to a yellow solid (4.0 g, 82%)

ORD-Eintrag

ord-c26ef05e381f4ee0963185b4de7e87a5

Quelldatensatz

uspto-grants-2006_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07151105B2