Acetic Anhydride → 6-Fluoro-1,2-dihydroquinolin-2-one

HRID 860022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 860022
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N+:8]([O-])=[CH:7][CH:6]=[CH:5]2.C(OC(=O)C)(=[O:15])C>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:15])[CH:6]=[CH:5]2

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 198986466-Fluoro-1-oxo-1lambda~5~-quinoline

Produkt 1

HCID 98340436-Fluoro-1,2-dihydroquinolin-2-one

Versuchsvorschrift

A solution of 6-fluoroquinoline 1-oxide from Step B (5.0 g, 30.65 mmol) in acetic anhydride (30 mL) is heated at 110° C. for 6.5 hours. The reaction is allowed to stand at room temperature overnight. The solid (1.1 g) is collected and recrystallized from anhydrous ethanol (75 mL). The reddish crystals are collected by filtration and dried under high vacuum to give the title compound (0.653 g), m.p. dec. 269–270° C.

Aufarbeitung

  1. customThe solid (1.1 g) is collected
  2. customrecrystallized from anhydrous ethanol (75 mL)
  3. filtrationThe reddish crystals are collected by filtration
  4. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-426482cb18f346cc95904b856e8a76d2
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07153849B2

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