Sodium Sulfite → HCID 178506557, Verbindung

HRID 860148Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 860148
[O-]S([O-])=O.[Na+].[Na+].[CH:7]1([C:10]2[NH:11][C:12]([I:16])=[C:13](I)[N:14]=2)[CH2:9][CH2:8]1>O.C(O)C>[CH:7]1([C:10]2[NH:14][CH:13]=[C:12]([I:16])[N:11]=2)[CH2:9][CH2:8]1

Komponenten

5

Edukt 2

HCID 24437Sodium SulfiteHCID 219853952-Cyclopropyl-4,5-diiodo-1h-imidazole

Produkt 1

HCID 178506557HCID 178506557, VerbindungAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Na2SO3 (10.42 g, 82.65 mmol) was suspended in 40 ml water and 20 ml ethanol. 2-Cyclopropyl-4,5-diiodo-1H-imidazole (3500 mg, 9.72 mmol) was added and the mixture was stirred at reflux for 16 hours. The reaction mixture was concentrated to 20 ml and then filtered. The solid was dried for 5 hours at 50° C. under reduced pressure (<10 mbar) to get a light brown solid (1.50 g, 66%), MS: m/e=235.1 (M+H+).

Aufarbeitung

  1. temperatureat reflux for 16 hours
  2. concentrationThe reaction mixture was concentrated to 20 ml
  3. filtrationfiltered
  4. customThe solid was dried for 5 hours at 50° C. under reduced pressure (<10 mbar)

Quellen und Nachweise

ORD-Eintrag
ord-8aeec3f858c043699f8c6f8803af9be4
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07153874B2

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