Water → HCID 57444530, Verbindung

HRID 860416Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 860416
[C:1]([C:4]([C:18](=[O:27])[C:19]1[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=1)(C(=O)C)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:3])[CH3:2].C(OCC)(=O)C.O>FC(F)(F)C(O)=O>[C:25]([C:22]1[CH:21]=[CH:20][C:19]([C:18]([CH:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:27])=[CH:24][CH:23]=1)#[N:26]

Komponenten

5

Edukt 3

HCID 962WaterHCID 8857Ethyl AcetateHCID 57444529Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate

Produkt 1

HCID 57444530HCID 57444530, VerbindungAusbeute 72,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate (3.5 g) was dissolved in trifluoroacetic acid (12.6 ml) and the mixture was stirred at 20° C. for 15 minutes. The mixture was partitoned between ethyl acetate and water. The organic layer was separated, washed with water, aqueous sodium bicarbonate and brine, dried over MgSO4 (magnesium sulfate), and evaporated to give ethyl 7-(4-cyanobenzoyl)-8-oxononanoate (2.25 g) as an oil.

Aufarbeitung

  1. customThe organic layer was separated
  2. washwashed with water, aqueous sodium bicarbonate and brine
  3. dry with materialdried over MgSO4 (magnesium sulfate)
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e00be75486dc4cbcb2c46c3115462fa4
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07153854B2

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