Hydrochloric Acid → N1-hexanoylsulfanilamide

HRID 861186

Reaktionsgleichung

Reaktionsgleichung von HRID 861186
C(NC1C=CC(S(N)(=O)=O)=CC=1)(=O)C.C(Cl)(=O)CCCCC.Cl.C([NH:27][C:28]1[CH:44]=[CH:43][C:31]([S:32]([NH:35][C:36](=[O:42])[CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])(=[O:34])=[O:33])=[CH:30][CH:29]=1)(=O)C>O.N1C=CC=CC=1>[C:36]([NH:35][S:32](=[O:33])([C:31]1[CH:30]=[CH:29][C:28]([NH2:27])=[CH:44][CH:43]=1)=[O:34])(=[O:42])[CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 8482N4-AcetylsulfanilamideHCID 67340Hexanoyl chlorideHCID 54008860HCID 54008860, Verbindung

Produkt 1

HCID 14338356N1-hexanoylsulfanilamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1049PyridineLösungsmittel

Versuchsvorschrift

N1 -hexanoylsulfanilamide was prepared as follows. To a mixture of N4 -acetylsulfanilamide (55.0 g) and pyridine (54 mL) at 95° C. was added hexanoyl chloride (28.8 g) over a period of 20 min. After an additional hour the reaction mixture was cooled to room temperature and the reaction was worked up by diluting with 600 mL D.I. water and acidifying with aqueous HCl. The product of this reaction, N4 -acetyl-N1 -hexanoylsulfanilamide, was isolated by filtration and washed with D.I. water (700 mL) to afford an off-white solid. This material was carried directly to the next step.

Aufarbeitung

  1. additionby diluting with 600 mL D.I
  2. customwas isolated by filtration
  3. washwashed with D.I
  4. customwater (700 mL) to afford an off-white solid

Quellen und Nachweise

ORD-Eintrag
ord-4ae0af2c5247494da797655fdc01bac6
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05713988

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