Chlorine → Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylate, monohydrochloride

HRID 861998Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 861998
[CH2:1]([O:3][P:4]([CH:9]([OH:24])[C:10]1[N:15]2[CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].P(CC1C2N(C=C(C(O)=O)N=2)C=CC=1)(O)(O)=O.O1CCOCC1.[Cl:48]Cl>>[ClH:48].[CH2:1]([O:3][P:4]([CH:9]([OH:24])[C:10]1[N:15]2[CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]

Komponenten

5

Edukt 4

HCID 24526ChlorineHCID 312751,4-DioxaneHCID 15233873Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylateHCID 19701381HCID 19701381, Verbindung

Produkt 1

HCID 131720464Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylate, monohydrochlorideAusbeute 99 %

Versuchsvorschrift

The product from Example 55 (1.2 g, 3.37 mmol) was dissolved in CH2 Cl2 (15 mL) and treated with 6N HCl in dioxane (0.56 mL, 3.37 mmol). The resulting salt was precipitated with Et2O, filtered, washed with Et2O, and dried in vacuo to give 1.3 g (99%) of the title product.

Aufarbeitung

  1. customThe resulting salt was precipitated with Et2O
  2. filtrationfiltered
  3. washwashed with Et2O
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f854f89bc13243bfb3e84961edbbc3f3
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05716964

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