Sodium borohydride → Benzenemethanol, 5-bromo-2-(methoxymethoxy)-

HRID 862056Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 862056
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][O:12][CH3:13])=[C:6]([CH:9]=1)[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][O:12][CH3:13])=[C:6]([CH:9]=1)[CH2:7][OH:8]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 197016265-Bromo-2-(methoxymethoxy)benzaldehyde

Produkt 1

HCID 54142346Benzenemethanol, 5-bromo-2-(methoxymethoxy)-Ausbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 5-bromo-2-methoxymethoxybenzaldehyde (5.00 g) in methanol (50 ml) was added, at 0° C., sodium borohydride (0.46 g). The mixture was stirred for 30 minutes at the same temperature, which was then concentrated. To the concentrate was added ethyl acetate, and the mixture was washed with an aqueous solution of potassium hydrogensulfate and a saturated aqueous saline solution, successively. The organic layer was dried (anhydrous magnesium sulfate), which was then concentrated to leave 5-bromo-2-methoxymethoxybenzyl alcohol (5.04 g) as a pale yellow oily product.

Aufarbeitung

  1. concentrationwas then concentrated
  2. additionTo the concentrate was added ethyl acetate
  3. washthe mixture was washed with an aqueous solution of potassium hydrogensulfate
  4. dry with materialThe organic layer was dried (anhydrous magnesium sulfate), which
  5. concentrationwas then concentrated

Quellen und Nachweise

ORD-Eintrag
ord-0a810795ea7145fd8dc67a46d3fa7d98
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05716971

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