Pyrazole-4-carboxylic acid → Methyl 1H-pyrazole-4-carboxylate

HRID 862479Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 862479
[NH:1]1[CH:5]=[C:4]([C:6]([OH:8])=[O:7])[CH:3]=[N:2]1.[CH3:9][O-].[Na+]>CO.S(=O)(=O)(O)O>[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH3:9])=[O:7])[CH:3]=[N:2]1

Komponenten

5

Edukt 2

HCID 3015937Pyrazole-4-carboxylic acidHCID 10942334Sodium Methoxide

Produkt 1

HCID 9793760Methyl 1H-pyrazole-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittel2×HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

4-Pyrazolecarboxylic acid (514 mg) was dissolved in methanol (10 ml) and sulfuric acid (0.25 ml), and the mixture was stirred at room temperature for 2 hours, followed by refluxing under heating for 4 hours. After cooling, a 28% solution (0.95 ml) of sodium methylate in methanol was added to the reaction mixture for neutralization and the solvent was distilled away. Chloroform was added to the residue, and the residue was washed with water and brine and dried over anhydrous magnesium sulfate. The solvent was distilled away to give 433 mg of the title compound.

Aufarbeitung

  1. temperatureby refluxing
  2. temperatureunder heating for 4 hours
  3. temperatureAfter cooling
  4. distillationthe solvent was distilled away
  5. additionChloroform was added to the residue
  6. washthe residue was washed with water and brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. distillationThe solvent was distilled away

Quellen und Nachweise

ORD-Eintrag
ord-03a04da955174a06bbf4cc1d968eb199
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05719155

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