Methyl iodide → 3-Methoxyquinoline

HRID 863280

Reaktionsgleichung

Reaktionsgleichung von HRID 863280
[C:1](=O)([O-])[O-].[K+].[K+].CI.[OH:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2>CN(C)C=O.C(OCC)C>[CH3:1][O:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2

Komponenten

6

Edukt 3

HCID 6328Methyl iodideHCID 113763-HydroxyquinolineHCID 11430Potassium Carbonate

Produkt 1

HCID 5758073-Methoxyquinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1.05 g of anhydrous potassium carbonate and 0.48 ml of methyliodide are added to a solution of 1.0 g of 3-hydroxyquinoline in 8.5 ml of dimethylformamide and the reaction mixture is stirred at room temperature for 18 h. It is diluted with diethyl ether, the resulting suspension is filtered and the filtrate is concentrated. The crude product is purified by FC over 60 g of silica gel (mobile phase F) to give 3-methoxyquinoline: Rf (A)=0.53.

Aufarbeitung

  1. filtrationthe resulting suspension is filtered
  2. concentrationthe filtrate is concentrated
  3. customThe crude product is purified by FC over 60 g of silica gel (mobile phase F)

Quellen und Nachweise

ORD-Eintrag
ord-8ee420d42c2148ab89a0b94ec8ce8b40
Quelldatensatz
uspto-grants-1998_02
Patentnummer
US05719141

Verknüpfte Notizen

Wird geladen…