Hydrochloric Acid → alpha-(3,4-Dimethoxyphenyphenyl)-3,4-dihydro-6,7-dimethoxy-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinolinepentanenitrile monohydrochloride

HRID 863868Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 863868
CO[C:3]1[CH:4]=[C:5]([C:11]([S:31][C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)([CH2:14][CH2:15][CH2:16][N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][C:21]([O:29][CH3:30])=[C:22]([O:27][CH3:28])[CH:23]=3)[CH2:18]2)[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1OC.[ClH:39].[CH2:40]([O:42][CH2:43][CH3:44])C>C(O)C>[ClH:39].[CH3:40][O:42][C:43]1[CH:44]=[C:19]([C:6]2[CH:7]=[CH:8][CH:3]=[CH:4][C:5]=2[C:11]([S:31][C:32]2[CH:33]=[CH:34][C:35]([CH3:38])=[CH:36][CH:37]=2)([CH2:14][CH2:15][CH2:16][N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][C:21]([O:29][CH3:30])=[C:22]([O:27][CH3:28])[CH:23]=3)[CH2:18]2)[C:12]#[N:13])[CH:20]=[CH:21][C:22]=1[O:27][CH3:28]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 10744844alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinolinepentanenitrile

Produkt 1

HCID 67811830alpha-(3,4-Dimethoxyphenyphenyl)-3,4-dihydro-6,7-dimethoxy-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinolinepentanenitrile monohydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 1.43 g of α-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolinepentanenitrile in 40 mL of diethyl ether, with stirring, is added 0.617 mL of a 4.71M solution of hydrogen chloride in absolute ethyl alcohol. The reaction mixture is then stirred for 15 hours while sealed. The title product is then collected by filtration, washed with ether, and dried under vacuum to give 1.32 g of the desired product as pink crystals.

Aufarbeitung

  1. customwhile sealed
  2. filtrationThe title product is then collected by filtration
  3. washwashed with ether
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-182cd74aa14a47748907647a839f6c94
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05561141

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