Benzylamine → 4-[3-(N-benzylamino)propylthio)pyridine

HRID 863971Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 863971
O[CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1.CS(Cl)(=O)=O.[CH2:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(Cl)Cl>[CH2:17]([NH:24][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Komponenten

5

Edukt 3

HCID 7504BenzylamineHCID 31297Methanesulfonyl chlorideHCID 190791344-(3-Hydroxypropylthio)pyridine

Produkt 1

HCID 190791904-[3-(N-benzylamino)propylthio)pyridineAusbeute 161,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In 150 ml of methylene chloride were dissolved 5.22 g (30.8 mmol) of 4-(3-hydroxypropylthio)pyridine and 5.16 ml (37.0 mmol) of triiethylamine, methanesulfonyl chloride [2.86 ml (37.0 mmol)] was added, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate and water and dried. Then the solvent was distilled off. 2.62 ml (24.0 mmol) of benzylamine was added to the residue, and the mixture was heated at 80° C. for 3 hours. After cooling, the mixture was purified by column chromatography (eluent: chloroform/methanol=25:1) to obtain 10 g of the desired compound (yield: 16.1%, yellow oil).

Aufarbeitung

  1. additionwas added
  2. washThe reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate and water
  3. customdried
  4. distillationThen the solvent was distilled off
  5. temperaturethe mixture was heated at 80° C. for 3 hours
  6. temperatureAfter cooling
  7. customthe mixture was purified by column chromatography (eluent: chloroform/methanol=25:1)

Quellen und Nachweise

ORD-Eintrag
ord-8ca6f62b6c864b9dbea14244fd8eeaf4
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05561147

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