1-Boc-4-(2-nitrophenyl)piperazine → tert-Butyl 4-(2-aminophenyl)piperazine-1-carboxylate

HRID 864384Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 864384
[CH3:1][C:2]([CH3:22])([O:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N+:19]([O-])=O)[CH2:9][CH2:8]1)=[O:6])[CH3:3]>C(O)C.[Pd]>[CH3:3][C:2]([CH3:22])([O:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH2:19])[CH2:9][CH2:8]1)=[O:6])[CH3:1]

Komponenten

4

Edukt 1

HCID 219352101-Boc-4-(2-nitrophenyl)piperazine

Produkt 1

HCID 2795530tert-Butyl 4-(2-aminophenyl)piperazine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine (PREPARATION 12, 7.61 g) is dissolved in ethanol (150 ml). Palladium on carbon (10%, 0.75 g) is added and the reaction is hydrogenated at 45 psi for 6 hr. The mixture is filtered thru celite and concentrated under reduced pressure to give the title compound.

Aufarbeitung

  1. filtrationThe mixture is filtered thru celite
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d734103bf569437b8a5ede11b22963ff
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05563142

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