Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate → ethyl 2-(4-amino-1H-imidazol-1-yl)octanoate

HRID 864673

Reaktionsgleichung

Reaktionsgleichung von HRID 864673
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[N:6]1[CH:10]=[C:9]([N+:11]([O-])=O)[N:8]=[CH:7]1)[CH3:2].[H][H]>[Pd]>[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[N:6]1[CH:10]=[C:9]([NH2:11])[N:8]=[CH:7]1)[CH3:2]

Komponenten

4

Edukt 2

HCID 10062368Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 15222343ethyl 2-(4-amino-1H-imidazol-1-yl)octanoateAusbeute 100,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

A mixture of 5.9 g of 4-nitro-α-hexyl-1H-imidazole-1-acetic acid ethyl ester, 3 g of palladium-on-carbon and 150 ml of absolute alcohol were subjected to catalytic hydrogenation. Both theoretical and actual hydrogen uptake was 73 pounds. The catalyst was removed by filtration and the filtrate concentrated in vacuo to provide 5.3 g of the desired title intermediate which was used directly.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-67ed31b84955402790252a01d00d41c0
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05563278

Verknüpfte Notizen

Wird geladen…