Thionyl Chloride → 1-Benzyl-3-(chloromethyl)pyrrolidine

HRID 865

Reaktionsgleichung

Reaktionsgleichung von HRID 865
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13]O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][Cl:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 5176654(1-Benzylpyrrolidin-3-yl)methanol

Produkt 1

HCID 123645181-Benzyl-3-(chloromethyl)pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.

Aufarbeitung

  1. customThe mixture was evaporated
  2. dissolutionthe residue was dissolved in water

Quellen und Nachweise

ORD-Eintrag
ord-1537debbdfcd4c9fb2d97af472b6fc7c
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723444

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