N-bromobutanimide → HCID 18941095, Verbindung

HRID 865107

Reaktionsgleichung

Reaktionsgleichung von HRID 865107
[CH3:1][C:2]1[S:3][C:4]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:5]=2[N:6]=1.[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:15][CH2:1][C:2]1[S:3][C:4]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:5]=2[N:6]=1

Komponenten

5

Edukt 2

HCID 67184N-bromobutanimideHCID 75892Naphtho[1,2-d]thiazole, 2-methyl-

Produkt 1

HCID 18941095HCID 18941095, VerbindungAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7187Benzoyl PeroxideKatalysatorHCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

To 3.98 g of 2-methylnaphtho[1,2-d]thiazole dissolved in carbon tetrachloride (40 ml) was added 3.56 g of N-bromosuccinimide and 0.20 g of benzoyl peroxide, followed by 6 hours of heating under reflux. After cooling the reaction solution, insoluble matter was removed by filtration, and the solvent was evaporated. The residue was subjected to silica gel column chromatography eluted with hexane-chloroform (5:1) to obtain 3.50 g (63%) of 2-bromomethylnaphtho[1,2-d]thiazole.

Aufarbeitung

  1. temperatureof heating
  2. temperatureunder reflux
  3. temperatureAfter cooling the reaction solution, insoluble matter
  4. customwas removed by filtration
  5. customthe solvent was evaporated
  6. washeluted with hexane-chloroform (5:1)

Quellen und Nachweise

ORD-Eintrag
ord-13d380465b7a413fade7138bad7130a2
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05565479

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