Lactic Acid → N,N'-1,2-ethanediylbislactamide

Temperatur

125 °C

Lactic acid (441 g; 4.90 moles) was placed in a reaction flask equipped with a distillation head. Under a nitrogen atmosphere, ethylene diamine (147 g; 2.45 moles) was slowly added with stirring to the reaction flask. During the course of the addition, the reaction mixture turned a deep orange and the temperature reached 140° C. The reaction mixture was then heated at 150° C. overnight with the water being removed by distillation. The reaction mixture was allowed to cool to 125° C. then it was poured into an aluminum pan and allowed to cool to ambient temperature to provide 468 g of crude product. This material was recrystallized from methanol (1.9 L) to provide N,N'-1,2-ethanediylbislactamide, m.p. 188° C.

1. customequipped with a distillation head
2. additionDuring the course of the addition
3. customreached 140° C
4. customremoved by distillation
5. additionit was poured into an aluminum pan
6. temperatureto cool to ambient temperature
7. customto provide 468 g of crude product
8. customThis material was recrystallized from methanol (1.9 L)

ORD-Eintrag

ord-d54f42a2529742d9bc5406ba76439fd2

Quelldatensatz

uspto-grants-1996_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05569450