Tetrahydrofuran → 3-Chloro-4-methoxybenzoyl chloride

HRID 866059

Reaktionsgleichung

Reaktionsgleichung von HRID 866059
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5](O)=[O:6].O1CCCC1.C(Cl)(=O)C([Cl:21])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([Cl:21])=[O:6]

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 1699823-Chloro-p-anisic acid

Produkt 1

HCID 47692993-Chloro-4-methoxybenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A stirred solution of 0.22 gram (0.0012 mole) of 3-chloro-4-methoxybenzoic acid in a small amount of tetrahydrofuran and chloroform was cooled to 0° C., and 0.12 mL (0.0014 mole) of oxalyl chloride was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature, where it was stirred for about 3.5 hours. After this time the reaction mixture was concentrated under reduced pressure, yielding 3-chloro-4-methoxybenzoyl chloride, which was dissolved in a small amount of tetrahydrofuran for later use.

Aufarbeitung

  1. additionUpon completion of addition
  2. concentrationAfter this time the reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ef7b2c9f6f784ede8ceb8024279c9555
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05569664

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