Phenylacetyl chloride → 2-(3-Phenylacetamido-4-hydroxyphenyl)propionitrile

HRID 866561Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 866561
[C:1]1([CH2:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][C:12]1[CH:13]=[C:14]([CH:19]([CH3:22])[C:20]#[N:21])[CH:15]=[CH:16][C:17]=1[OH:18]>N1C=CC=CC=1>[C:1]1([CH2:7][C:8]([NH:11][C:12]2[CH:13]=[C:14]([CH:19]([CH3:22])[C:20]#[N:21])[CH:15]=[CH:16][C:17]=2[OH:18])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 7679Phenylacetyl chlorideHCID 122026362-(3-Amino-4-hydroxyphenyl)propanenitrile

Produkt 1

HCID 543642522-(3-Phenylacetamido-4-hydroxyphenyl)propionitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Phenyl acetyl chloride (28.0 g.) was added over 20 minutes to a cooled stirred solution of 2-(3-amino-4-hydroxyphenyl) propionitrile (29.0 g.) in anhydrous pyridine (200 ml.) at 0°-3° C. After addition was complete, the mixture was heated at 100° C. for 1 hour. After evaporation under reduced pressure, 2-(3-phenylacetamido-4-hydroxyphenyl)propionitrile was isolated as an oil.

Aufarbeitung

  1. additionAfter addition
  2. customAfter evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1d3feb24f765494cbd144ef7f5a41f75
Quelldatensatz
uspto-grants-1978_07
Patentnummer
US04100168

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