HCID 20318584, Verbindung → 5-(2-Amino-1-hydroxyethyl)-o-anisamide

HRID 866777

Reaktionsgleichung

Reaktionsgleichung von HRID 866777
C([N:8](CC1C=CC=CC=1)[CH2:9][C:10]([C:12]1[CH:20]=[C:16]([C:17]([NH2:19])=[O:18])[C:15]([O:21][CH3:22])=[CH:14][CH:13]=1)=[O:11])C1C=CC=CC=1.[H][H]>O1CCCC1.C(O)C.[Pd]>[NH2:8][CH2:9][CH:10]([C:12]1[CH:20]=[C:16]([C:17]([NH2:19])=[O:18])[C:15]([O:21][CH3:22])=[CH:14][CH:13]=1)[OH:11]

Komponenten

6

Edukt 2

HCID 20318584HCID 20318584, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 203185835-(2-Amino-1-hydroxyethyl)-o-anisamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 5-(N,N-dibenzylglycyl)-o-anisamide (3.88g) in tetrahydrofuran (25 ml) and ethanol (125ml) was added to a pre-reduced suspension of 10% Pd/C (1.0g) in ethanol (25 ml). Uptake of hydrogen ceased within 14 hours. The catalyst was filtered off and the solvent evaporated under reduced pressure to leave 5-(2-amino-1-hydroxyethyl)-o-anisamide as a colourless gum.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4f0d162cc99e46d8bdd5aa4995cc500b
Quelldatensatz
uspto-grants-1978_07
Patentnummer
US04101579

Verknüpfte Notizen

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