Hydrazine hydrate (1:1) → 2-Oxazolemethanamine, 5-(4-chlorophenyl)-, monohydrochloride

HRID 866853Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 866853
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH2:13][N:14]3C(=O)C4=CC=CC=C4C3=O)=[N:10][CH:9]=2)=[CH:4][CH:3]=1.O.NN>C(O)C>[ClH:1].[NH2:14][CH2:13][C:11]1[O:12][C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:9][N:10]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 22762753HCID 22762753, Verbindung

Produkt 1

HCID 30492642-Oxazolemethanamine, 5-(4-chlorophenyl)-, monohydrochlorideAusbeute 154,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3.4 g of N-[5-(4-chlorophenyl)-2-oxazolyl]methylphthalimide and 0.55 g of 100% hydrazine hydrate in 50 ml of ethanol was heated at reflux for one hour. At the end of this period, the formed precipitate was filtered off, and the filtrate was evaporated to dryness in vacuo. The residue was shaken with 2N HCl - chloroform and the 2N HCl - layer was evaporated to dryness under vacuo. The residue was recrystallized from ethanol to give 1.9 g (78 percent) of 2-aminomethyl-5-(4-chlorophenyl) oxazole hydrochloride, M.P. 200° C (decomposition).

Aufarbeitung

  1. temperatureat reflux for one hour
  2. filtrationAt the end of this period, the formed precipitate was filtered off
  3. customthe filtrate was evaporated to dryness in vacuo
  4. customthe 2N HCl - layer was evaporated to dryness under vacuo
  5. customThe residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-e9312d285a2d4482a7353beb8ea8e34e
Quelldatensatz
uspto-grants-1978_07
Patentnummer
US04101660

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