Ammonia → N-(4-Chlorobenzhydryl)thiourea

HRID 866857

Reaktionsgleichung

Reaktionsgleichung von HRID 866857
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH:6]([N:13]=[C:14]=[S:15])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH3:18]>CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]([NH:13][C:14]([NH2:18])=[S:15])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:16][CH:17]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 218286174-Chlorobenzhydryl isothiocyanate

Produkt 1

HCID 21312364N-(4-Chlorobenzhydryl)thiourea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of 4-chlorobenzhydryl isothiocyanate [5.2g (0.02M)] in 50 mls of dry ether at 0° C is treated with NH3 (anhyd.) for 1/2 hour while maintaining a temperature of 0° C with stirring. Stirring is continued an additional 1.5 hours at 9° to 10° C. during which time a white solid appears. The crude thiourea is filtered and washed thoroughly with ether; mp 173°-5° C. The filtrate is concentrated in vacuo to yield additional product. The combined crops of N-(4-chlorobenzhydryl) thiourea are used in the next step without further purification.

Aufarbeitung

  1. stirringStirring
  2. filtrationThe crude thiourea is filtered
  3. washwashed thoroughly with ether
  4. concentrationThe filtrate is concentrated in vacuo
  5. customto yield additional product
  6. customThe combined crops of N-(4-chlorobenzhydryl) thiourea are used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-edd07cff828446d087e0a9b78a66eaf4
Quelldatensatz
uspto-grants-1978_07
Patentnummer
US04101659

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