Ethanol → HCID 13882134, Verbindung

HRID 867384Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 867384
[C:1]([C:3]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[N:6]=[CH:5][C:4]=1[C:15]([O:17]CC)=[O:16])#[N:2].[OH-].[K+].C([OH:24])C>O>[C:15]([C:4]1[CH:5]=[N:6][N:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[C:3]=1[C:1]([NH2:2])=[O:24])([OH:17])=[O:16]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 13772963Ethyl 5-cyano-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

Produkt 1

HCID 13882134HCID 13882134, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A 2.5 g. portion of ethyl 5-cyano-1-(4-fluorophenyl)-4-pyrazolecarboxylate was combined with 2.6 g. of potassium hydroxide and stirred under reflux in 100 ml. of denatured ethanol for 4 hours. It was then cooled, made acid, diluted with water, and concentrated under vacuum to obtain 2.8 g. of the desired compound, m.p. 232° dec. after recrystallization from acetone. It was identified by elemental analysis.

Aufarbeitung

  1. temperatureunder reflux in 100 ml
  2. temperatureIt was then cooled
  3. concentrationconcentrated under vacuum
  4. customto obtain 2.8 g
  5. customof the desired compound, m.p. 232° dec. after recrystallization from acetone

Quellen und Nachweise

ORD-Eintrag
ord-da49caf879b34e3faf5b1248613c8a40
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04775409

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