Dimethylformamide → HCID 67601003, Verbindung

HRID 867605

Reaktionsgleichung

Reaktionsgleichung von HRID 867605
[CH3:1][C:2]1[CH2:21][S:20][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:19])[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:22]([OH:24])=[O:23].CN(C=O)C>C(O)C>[CH3:1][C:2]1[CH2:21][S:20][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:22]([OH:24])=[O:23].[CH2:7]([OH:8])[CH3:6]

Komponenten

4

Edukt 2

HCID 6228DimethylformamideHCID 27447Cephalexin

Produkt 1

HCID 67601003HCID 67601003, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A slurry of 47.4 g of cephalexin bis-DMF solvate in 600 ml of 3A ethanol (K.F=0.03%) was stirred at room temperature and seeded with a few milligrams of a product from an earlier like preparation. After stirring the mixture 5 hours at room temperature, the ethanol in the mixture was evaporated until the total weight of the resulting slurry was 230 g. Filtration provided a crystalline cephalexin ethanol solvate. Air drying the product overnight, provided 35.1 g of crystalline desolvated cephalexin ethanolate.

Aufarbeitung

  1. customearlier like preparation
  2. customthe ethanol in the mixture was evaporated until the total weight of the resulting slurry
  3. filtrationFiltration

Quellen und Nachweise

ORD-Eintrag
ord-dfcfa13629f24651a61be0a0ae541ddf
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04775751

Verknüpfte Notizen

Wird geladen…