Dichloromethane → (trans)-3-Amino-4-ethyl-2-oxo-1-azetidinesulfonic acid

HRID 867653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 867653
C([N+](CCCC)(CCCC)CCCC)CCC.C(OC([NH:25][C@H:26]1[C@H:29]([CH2:30][CH3:31])[N:28]([S:32]([O-:35])(=[O:34])=[O:33])[C:27]1=[O:36])=O)(C)(C)C.ClCCl>C(O)=O>[NH2:25][C@H:26]1[C@H:29]([CH2:30][CH3:31])[N:28]([S:32]([OH:35])(=[O:33])=[O:34])[C:27]1=[O:36]

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 131714274(trans)-3-t-Butoxycarbonylamino-4-ethyl-2-oxo-1-azetidinesulfonic acid, tetrabutylammonium salt

Produkt 1

HCID 13575528(trans)-3-Amino-4-ethyl-2-oxo-1-azetidinesulfonic acidAusbeute 34,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

(trans)-3-t-Butoxycarbonylamino-4-ethyl-2-oxo-1-azetidinesulfonic acid, tetrabutylammonium salt (6.75 g) in 40 ml of 98% formic acid is stirred for 3 hours at ambient temperature. Dichloromethane (60 ml) is added and the mixture is refrigerated for about 16 hours. The resulting precipitate is separated by filtration and then dried in vacuo to yield 0.85 g of the title compound, melting point 185° C., dec.

Aufarbeitung

  1. customThe resulting precipitate is separated by filtration
  2. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f0bb8e6b1f844640b2388124c3912948
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04775670

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