2-Pyridineethanamine → 1,8,8-Trimethyl-3-[2-(2-pyridinyl)ethyl]-3-azabicyclo[3.2.1]octane-2,4-dione

HRID 867944

Reaktionsgleichung

Reaktionsgleichung von HRID 867944
[C:1]1(=[O:13])[O:10][C:8](=O)[CH:7]2[CH2:11][CH2:12][C:2]1([C:4]2([CH3:6])[CH3:5])[CH3:3].[NH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>N1C=CC=CC=1>[CH3:3][C:2]12[C:4]([CH3:5])([CH3:6])[CH:7]([CH2:11][CH2:12]1)[C:8](=[O:10])[N:14]([CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[C:1]2=[O:13]

Komponenten

4

Edukt 2

HCID 759192-PyridineethanamineHCID 948341,8,8-Trimethyl-3-oxabicyclo[3.2.1]octane-2,4-dione

Produkt 1

HCID 142350661,8,8-Trimethyl-3-[2-(2-pyridinyl)ethyl]-3-azabicyclo[3.2.1]octane-2,4-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A mixture of (-) camphoric anhydride 5 g (0.029 mol), 2-(2-aminoethyl)pyridine 3.6 (0.03 mol) and 50 ml of pyridine was refluxed overnight. The solvent is removed under reduced pressure and the remaining oil boiled in 20 ml of ethanol and allowed to cool.

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. customThe solvent is removed under reduced pressure
  3. temperatureto cool

Quellen und Nachweise

ORD-Eintrag
ord-14d27eb0342e4f14801d1f2da1572273
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04777254

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