Sodium Hydroxide → HCID 14278968, Verbindung

HRID 868166Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 868166
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[CH:11]=[N:10][C:9]([C:17]([O:19]C)=[O:18])=[CH:8]2>O.O.O1CCCC1>[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[CH:11]=[N:10][C:9]([C:17]([OH:19])=[O:18])=[CH:8]2

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 11096910HCID 11096910, Verbindung

Produkt 1

HCID 14278968HCID 14278968, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 21881883Oxolane--water (1/1)Lösungsmittel

Versuchsvorschrift

A solution of sodium hydroxide (4.38 g, 109.4 mmol) in 70 ml of water was added to a solution of 6,7-dimethoxy-3-isoquinolinecarboxylic acid, methyl ester (22.54 g, 91.2 mmol) in 1800 ml of water:tetrahydrofuran 1:1. After stirring overnight at room temperature, the tetrahydrofuran was distilled off in vacuo and the pH of the remaining aqueous solution was brought to 3 with 3N hydrochloric acid. The resulting precipitate was filtered off with suction, washed with water and dried in vacuo. Yield: 19.57 g; melting point 228.2° C.

Aufarbeitung

  1. distillationthe tetrahydrofuran was distilled off in vacuo
  2. filtrationThe resulting precipitate was filtered off with suction
  3. washwashed with water
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b64f8fad54da4ef9a399b51e4ade7450
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04777252

Notizen zur Reaktion

Wird geladen…