Hydrochloric Acid → 3-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester

HRID 868476

Reaktionsgleichung

Reaktionsgleichung von HRID 868476
ClNCl.[ClH:4].[CH3:5][CH:6]([CH2:18][CH3:19])[CH2:7][O:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1>C(O)(=O)C>[CH3:5][CH:6]([CH2:18][CH3:19])[CH2:7][O:8][C:9](=[O:17])[C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[C:14]([Cl:4])[CH:15]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 76939ChlorimideHCID 13530949Benzoic acid, 4-hydroxy-, 2-methylbutyl ester

Produkt 1

HCID 230416823-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

On the other hand, dichloroamine T (28.0 g, 0.12 mol) was dissolved in acetic acid (450 ml), and hydrochloric acid (1.5 ml) was added. The resulting solution was dropwise added to a solution of the above p-hydroxybenzoic acid 2-methyl-butyl ester (50 g, 0.24 mol) dissolved in acetic acid (450 ml), followed by refluxing the mixture, allowing to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3-chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester (42 g) (b.p. 135°~138° C./4 mmHg).

Aufarbeitung

  1. temperatureby refluxing the mixture
  2. distillationdistilling off acetic acid
  3. filtrationfiltering off

Quellen und Nachweise

ORD-Eintrag
ord-d758b38bf38540e5843d0f8742dd452f
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04780242

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