p-Toluenesulfonic acid → 2-(2,3-Dihydrobenzofuran-5-yl)-1-morpholinoethanethione

HRID 868619Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 868619
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([C:10]1[CH:11]=[CH:12][C:13]2[O:17][CH2:16][CH2:15][C:14]=2[CH:18]=1)(=O)[CH3:8].[S].C1(C)C=CC([S:26](O)(=O)=O)=CC=1>CO>[O:17]1[C:13]2[CH:12]=[CH:11][C:10]([CH2:7][C:8]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[S:26])=[CH:18][C:14]=2[CH2:15][CH2:16]1

Komponenten

6

Edukt 4

HCID 6101p-Toluenesulfonic acidHCID 8083MorpholineHCID 1452201-(2,3-Dihydro-5-benzofuranyl)ethanoneHCID 5362487Sulfur

Produkt 1

HCID 137043802-(2,3-Dihydrobenzofuran-5-yl)-1-morpholinoethanethione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Morpholine (1.5 ml), 2,3-dihydro-5-acetylbenzofuran (2.0 g), sulfur (0.395 g) and p-toluene sulfonic acid (0.060 g) were heated at reflux. After 3 hours, the reaction mixture was cooled and 6 ml of methanol added. This solution was further cooled which precipitated the morpholide. The precipitate was filtered and washed with cold methanol to give 2,3-dihydrobenzofuran-5-ylthioacetic acid morpholide, m.p.--144°-147° C.

Aufarbeitung

  1. temperatureat reflux
  2. temperaturethe reaction mixture was cooled
  3. temperatureThis solution was further cooled which
  4. customprecipitated the morpholide
  5. filtrationThe precipitate was filtered
  6. washwashed with cold methanol

Quellen und Nachweise

ORD-Eintrag
ord-9d3301cc607748479d10fed339056f31
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04780480

Notizen zur Reaktion

Wird geladen…