Divinylbenzene-styrene → HCID 86742494, Verbindung

HRID 868646

Reaktionsgleichung

Reaktionsgleichung von HRID 868646
Cl.[CH3:2][O:3][C:4](=[O:30])[C@H:5]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[NH:6][C:7](=[O:22])[C@:8]([C:14]([N:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:15])([CH2:10][C:11](=[O:13])[OH:12])[NH2:9].C(=O)(O)[O-].[Na+].C=CC1C=CC=CC=1.C(C1C=CC=CC=1C=C)=C>O>[CH3:2][O:3][C:4](=[O:30])[C@H:5]([CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[NH:6][C:7](=[O:22])[C@:8]([C:14]([N:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:15])([CH2:10][C:11](=[O:12])[OH:13])[NH2:9]

Komponenten

5

Edukt 3

HCID 174664Divinylbenzene-styreneHCID 516892Sodium BicarbonateHCID 86742495HCID 86742495, Verbindung

Produkt 1

HCID 86742494HCID 86742494, VerbindungAusbeute 88,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of DL-2-piperidinecarbonyl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride (2.1 g) in 50 ml water was neutralized with sodium bicarbonate and passed through a column (50 ml) packed with an adsorption resin of styrene/divinylbenzene type (Mitsubishi Chemical Industries, Ltd., "Adsorption Resin SP-207"). After washing the column with 200 ml water, the adsorbed portion was eluted with 200 ml of water/methanol (50/50 by volume), and the solvents were removed by distillation, affording 1.7 g of white powder M.p.: 225°-227° C.

Aufarbeitung

  1. washAfter washing the column with 200 ml water
  2. washthe adsorbed portion was eluted with 200 ml of water/methanol (50/50 by volume)
  3. customthe solvents were removed by distillation

Quellen und Nachweise

ORD-Eintrag
ord-f4353958bfc6441a9daad1b8df273e8a
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04780528

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