alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride → alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester

HRID 868655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 868655
Cl.[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@:8]([NH2:19])([CH2:15][C:16](=[O:18])[OH:17])[NH:9][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]>O>[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@:8]([NH2:19])([CH2:15][C:16](=[O:17])[OH:18])[NH:9][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]

Komponenten

3

Edukt 1

HCID 86742496alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride

Produkt 1

HCID 86742497alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl esterAusbeute 85,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1.8 g α-aminoisobutyryl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride in 50 ml water was allowed to pass through a column (50 ml) packed with a weakly basic anion-exchange resin (Dow Chemical Co., "IRA-68"), and the resin was washed with 100 ml water. The washings were added to the effluent, and the combined solution was concentrated under reduced pressure, giving 1.4 g of white powder. M.p.: 168°-170° C.

Aufarbeitung

  1. washthe resin was washed with 100 ml water
  2. additionThe washings were added to the effluent, and the combined solution
  3. concentrationwas concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e239165540134d59bfa22ec56a6f3d39
Quelldatensatz
uspto-grants-1988_10
Patentnummer
US04780528

Notizen zur Reaktion

Wird geladen…