Ammonium Hydroxide → Pyrimidine, 4-amino-6-chloro-2,5-dimethyl-

Temperatur

80 °C

A microwave vial was charged with 4,6-dichloro-2,5-dimethylpyrimidine (523 mg, 2.95 mmol) and ammonium hydroxide (8 mL) in ethanol (4 mL). The vial was heated to 80° C. and stirred for 8 h. After concentration under reduced pressure, the reaction mixture was extracted with EtOAc (15 mL×8). The combined organic layers were washed with brine (30 mL), dried over Na2SO4 and concentrated to give 6-chloro-2,5-dimethylpyrimidin-4-amine as a yellow solid (411 mg). MS (ESI): m/z 158 [M+H]+.

1. concentrationAfter concentration under reduced pressure
2. extractionthe reaction mixture was extracted with EtOAc (15 mL×8)
3. washThe combined organic layers were washed with brine (30 mL)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated

ORD-Eintrag

ord-ea626cb6c9be42e284ebcf6abfc8c613

Quelldatensatz

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08969349B2